Statins are blockbuster drugs that make billions for pharmaceutical companies. Research shows these drugs do little to make patients’ lives longer or better. Read The Truth About Statins by Dr Barbara Roberts, for another view.
Here, Australian physician Dr Joe Kosterich looks at conflicting research in two British medical journals, He says it is confusing enough for doctors, never mind patients.
Kosterich calls for patients to do research, question what their doctors say about statins, and not just to swallow any prescription whole. I second that. – Marika Sboros
By Joe Kosterich*
Conflicting views have again emerged about statin medications in two leading British medical journals. Used to lower cholesterol, statins have been the best-selling drugs of the past 25 years, with sales in the tens of billions of dollars.
The Lancet published a review claiming statins are safe, that side effects were overstated and that benefits outweigh the risks. The BMJ has taken an opposite view, claiming side effects are more common than admitted to and researchers have overstated the benefits.
This is confusing enough for doctors, let alone the public.
The confusion comes from three issues. The results of medical trials reflect the population involved in the trial. They may not be the same as those that end up being prescribed the medication. This is a vital point.
The value of statins in primary prevention (those with no established heart disease) is very different from secondary prevention (those with heart disease). Secondly, trials measure different “end points”. Many assess “proxy” end points, which do not always translate that well into the real world where people value living longer or feeling better.
Cholesterol, weight and even blood pressure are proxy measures. Nobody dies from them. They are risk factors for heart disease and stroke. But treating risk factors is not treating illness. We hope we are preventing illness, but this is not necessarily the case.
Most critically, though, is how researchers interpret trial data.
Cholesterol is a component of each and every cell in the human body. The rationale for lowering cholesterol levels is that this will reduce rates of heart disease and increase life expectancy.
Last year researchers published a review in which they noted that it was “first study ever to systematically evaluate statin trials using average postponement of death as the primary outcome”. In primary prevention, death was postponed 3.2 days and 4.1 days in secondary prevention.
This study was remarkable for two reasons. Firstly, that in 25 years of widespread use, at considerable expense to health systems, no one had ever done such an evaluation. Secondly, that the benefit in terms of life expectancy is non-existent.
How can this be?
It comes from the confusion of proxy health outcomes with actual health outcomes. Researchers have to record dates of birth and death. These are difficult to fudge. Someone is either dead or alive.
Thus life expectancy (or postponement of death) is a “hard” measure. So is whether someone has had a heart attack or not.
Click here to read: STATINS: MAD, BAD, SAD WORLD OF CHOLESTEROL DRUGS
Nobody can argue that these medications do not lower cholesterol. One can argue what difference does a lower level make?
Previous work has shown that lowering cholesterol and blood pressure had little effect on the progress of atherosclerosis (artery narrowing).
Another “hard” way of evaluating medications is the number needed to treat (NNT). This measures how many people need to take a medication and for how long, to benefit. In primary prevention, if 100 people take a statin medication for five years, 98.5% will get no benefit. Not a single life will be saved.
Less than 1% will avoid a heart attack and a smaller number will avoid a stroke. Some 10% will have muscle damage as a side effect and 1% will develop diabetes as a side effect.
In secondary prevention, the numbers are better. Some 2.6% will avoid a heart attack and 1.2% of lives will be saved over five years. Yet 96% get no benefit. The side effect percentages are the same.
Woman age 83 on statins; memory lapses, sore legs reported to MD who said: “You are just getting older…” [malpractice]
— Alan Watson (@DietHeartNews) September 18, 2016
It’s easy enough to criticise trials. The review on life extension covered only a six-year period (the length of the trials it examined). If we treble it to 20 years, this would at best lead to a postponement of death by 12 days or less, as the longer you live the more likely you eventually die of some other cause.
Experts have criticised the Lancet review for doing nothing more than rehashing previous data. The authors have refused to allow independent review of their data and lead author Sir Rory Collins has received considerable funding from statin manufacturers.
You can form your own view on the significance of this.
What is the bottom line?
It has become too easy to reclassify healthy people as having a condition needing treatment, generally medications with costs and side effects. The role of cholesterol (a minor risk factor for heart disease) has been overstated, as has the value of lowering it, which is not an end in itself.
Click here to read: STATINS STUDY? 21ST CENTURY MEDICAL CENSORSHIP, SAYS KENDRICK
We have all been sold the dangers of fats. Damming evidence from the US has revealed the role of the sugar industry in funding doctors to write reviews blaming fat rather than sugar in the diet as a health problem. Low-fat diets are not and never were healthy.
There are only two reasons to treat any condition in medicine: to improve the quality of life or extend life. Treatments, which do neither, in my opinion, are difficult to justify. Lowering cholesterol does not make people feel better. If it does not increase life expectancy, their widespread use needs to be seriously questioned.
You need to consider your unique situation and balance the risks and benefits. There is no one size fits all. Be questioning of what you are told about fats, cholesterol and statins and do your own research.
- This article first appeared in WAToday.com.au and is republished with permission
- *Click here to read