deadly medicine

I HAVE the greatest respect for the marvels of modern medicine and doctors who practise it as a calling. I’m not much of a fan of the ones who are in it for the money, who expect us to treat them as if they were omnipotent, omniscient creatures. Doctors are only human and fallible like the rest of us lesser mortals. The big difference between us and them is mostly that when they make mistakes, they can kill. That’s why I like doctors with open minds. Not so open that their brains fall out, as one wag put it; just enough to know orthodox medicine doesn’t have all the answers, and doctors would do a lot less harm if they prescribed real food instead of drugs. Here’s a look at doctors who say doctors should be a little more mindful about the medicine they practise. 

By Marika Sboros

Doctors have always had a name for it – iatrogenic disease – and for good reason. It comes …from the Greek word, iatros (doctor). It means doctor-caused disease. It’s a fancy name for doctor error. And it’s  incidence is unacceptably high worldwide in modern medicine, given theHippocratic injunction to doctors that they should”first do no harm”.

In the US, iatgrogenisis is described as the “third most fatal disease”. A disturbing fully referenced report in 2003, authored by orthodox as well as complementary medical doctors, suggests that the situation is even worse:  that the American medical system is the leading cause of death and injury in the US.

One of the problems is that many doctors are too quick to reach for the prescription pad. Cardiologists in particular act as if heart disease is from a deficiency of statins. Simple dietary change, going back to eating real food, can be a more effective, safer prescription, and not just for heart disease.

Dr Joe Kosterich

Dr Joe Kosterich

Dr Joe Kosterich is an Australian GP, author and speaker who has very firm views about doctors who overdo things, particularly when it comes to dishing out the drugs. In a blog on his website, titled Too much medicine, he makes the case for what is called  “de-prescribing” – a foreign concept to many doctors it seems.

“The bottom line is this,” says Kosterich: “Too many of us (and not just the elderly) are taking too many tablets for too long. Every time a prescription is due for renewal, fundamental questions needs to be asked. Is the reason this medication was commenced still valid? Is this medication still doing more good than harm? Ultimately, is there still a valid reason to be taking it?”

We will only get answers if we ask the questions, says Kosterich.

The purpose of any medical intervention, he rightly says, is to improve the quality of life or to extend life expectancy.

“The closer we get to the end of our lives the less that extending life expectancy is likely to be relevant. This is underlined by the fact that virtually no research is done on the benefits of most medications in those over the age of 65.”

In the UK, the issue has led to a groundbreaking Choosing Wisely campaign launched by the Academy of Medical Royal Colleges. It aims to  protect patients from the harm caused by “too much medicine”, and stop doctors from being life-takers instead of life-savers.

Choosing Wisely is an initiative developed in the US and Canada. It has become an international campaign, as other countries, including Australia, Germany, Italy, Japan, Netherlands, and Switzerland, have taken it on board.

The  authors of a breakthrough analysis in the British Medical Journal, say it’s “a clear sign that wasteful medical practices are a problem for all health systems”. The content is UK-focused, but  has relevance for doctors, patients and the practice of medicine the world over, including South Africa and its faltering National Health Insurance plan.

The analysis, titled Choosing Wisely in the UK: the Academy of Medical Royal Colleges’ initiative to reduce the harms of too much medicine, is led by top British cardiologist Dr Aseem Malhotra, a consultant clinical associate of the Academy.

Co-authors include  two of the arguably most important doctors in the UK: current Academy chair, forensic psychiatric professor and dame Sue Bailey, and former chair, paediatric professor Terence Stephenson, now chair of the British General Medical Council.

Aseem Malhotra

Dr Aseem Malhotra

Malhotra hasn’t come overnight to the realisation of inbuilt landmines facing his own profession. In an article in The Guardian in 2014, he warned of “a culture of over-investigation and over-treatment ” which he said was  now “one of the greatest threats to western health”.

In the US, Malhotra said estimates were that a third of all healthcare activity brings no benefit to patients. Examples of wasteful exercises, he told The Guardian, include excessive use of antibiotics, imaging for “non-sinister headaches”,  surgery when “watchful waiting is better” and “unwanted intensive care for patients at the end of life who would prefer hospice and home care”. In the US,  Malhotra says a fee-for-service model encourages high volume and expensive procedures.That is proving to be the case in South Africa as well.

In another article in The Guardian in 2015, under the headline Too much medicine can kill you, Malhotra said “misinformation and fear-mongering” in the medical profession  is common and one of the root causes is “undoubtedly driven by the commercial interests of the pharmaceutical industry”.

At heart, Malhotra says the sickness in the medical profession is because doctors have also been guilty – wittingly or otherwise  – of “exaggerating the benefits of medications often perceived as magic pills by patients when their benefits are often modest at best”.

Choosing Wisely is about stopping overzealous doctors in their  tracks. That means doctors who overtreat patients, send them for screening they don’t need, overdiagnose and overprescribe drugs, surgery and other treatment regimens that have little benefit.

It is also about stopping doctors from keeping alive patients whose bodies and minds are begging to be allowed to “slip this mortal coil”.

Doctors still overdiagnose and overtreat patients for diseases that may never cause much disturbance, never mind untimely death. They contribute to skyrocketing medical costs along the way. In best-case scenarios, it’s from doctors rushing in where even angels fear to tread, in their God-like quest to save lives and keep death at bay.

That makes the BMJ analysis a much-needed injection of life-giving blood into modern medicine, and the authors just the ones to dispense it.

The analysis by Malhotra, Bailey and Stephenson begins with an historical perspective that makes sobering reading on its own. The authors say the idea of doctors doing  medical procedures that do more harm than good is “as old as medicine itself”. By way of example, they cite Mesopotamian King Hammurabi who proclaimed a law “threatening overzealous surgeons with the loss of a hand or an eye” 3800 years ago.

A more recent example comes in 1915 cartoon by pioneering Boston surgeon Ernest Codman in which he mocked his colleague’s indifference to the harm they wrought on patients and posed the question: “I wonder if clinical truth is incompatible with medical science? Could my clinical professors make a living without humbug?”

Dr Codman cartoonThat was at the height of what the BMJ authors call “a surgical vogue for prophylactic appendicectomy” – presumably much like the prophylactic mastectomy, oophorectomy and hysterectomy Hollywood actress Angelina Jolie has undergone over the past year.

“Diagnosis drives treatment,” say the authors in the BMJ, and the tendency to overdiagnose and overtreat is growing stronger. They define overdiagnosis as when “individuals are diagnosed with conditions that will never cause symptoms or death” often as a “consequence of the enthusiasm of early diagnosis”. By overtreatment they mean treatment of these overdiagnosed conditions, encompassing treatment with “ minimal evidence of benefit”, or that is “ excessive (in complexity, duration, or cost) relative to alternative accepted standards”.

The authors say that hasn’t always been the case in Britain. Even before the introduction of the country’s National Health Service (NHS), they say the British medical tradition was characterised by “late adoption and cautious use of new medicines, procedures, and technologies”. In recent years, however, they say the UK has exhibited disturbing patterns of variation in use of medical and surgical interventions similar to the US, “though less extreme in absolute terms”.

Ingrained practices

The National Institute for Health and Care Excellence (NICE) set up in 1999 was in part meant to address “unwarranted variations in clinical practice and has identified over 800 clinical interventions for potential disinvestment”, the authors say. This hasn’t been enough to stop doctors from performing “ familiar or ingrained” practices.

Clearly, a prescription is required for “a different approach to that for introducing new treatments”.

The NHS has good systems for evidence appraisal and health technology assessment, but “better and simpler tools are needed to facilitate informed discussion in clinical settings”, the authors say.

“Without such robust and easily shared decision aids, systematically updated without bias, patients may be swayed by potential exaggerated claims in the media when new drugs or procedures are introduced.”

In adopting the initiative, the Academy of Royal Medical Colleges intends tackling underlying causes of overtreatment that include a culture of “more is better”, and the onus it places on doctors to “do something” at each consultation that has bred “unbalanced decision making”.

Just one effect is patients being offered what the authors call “low-hanging fruit”, including treatments with “minor benefit and minimal evidence despite the potential for substantial harm and expense”.

Defensive medicine

Such a culture “threatens the sustainability of high quality healthcare and stems from defensive medicine, patient pressures, biased reporting in medical journals, commercial conflicts of interest, and a lack of understanding of health statistics and risk”, the authors say. The Choosing Wisely initiative will also look at incentives to limit doctors’ activity.
In this regard, NICE has produced guidelines for quality measures in both primary and secondary health that should not be written in medical stone. The authors say that decisions “need to be made with reference to individual patient circumstances, the wishes of the patient, clinical expertise, and available resources”.

Another problem the authors have identified is doctors’ “health illiteracy”, which is well-documented, especially around understanding research data.

Doctors need training in managing unrealistic expectations of patients, say the authors. Doctors also need to avoid misleading patients unintentionally by communicating relative instead of absolute risk or numbers needed to treat.

The analysis quotes Gerd Gigerenzer, director of Harding Centre for Risk Literacy in Berlin, in a summary in 2009: “It is an ethical imperative that every doctor and patient understand the difference between absolute and relative risks, to protect patients against unnecessary anxiety and manipulation.”

That’s the problem, which is daunting enough in size and scope, but what about solutions?

The authors issue a clarion call to action and say next steps should include different payment incentives for doctors and hospitals, and that:

  • Doctors should provide patients with resources that increase understanding about potential harms of interventions, and help them to accept that doing nothing can often be the best approach.
  • Patients should feel free to ask questions such as, “Do I really need this test or procedure? What are the risks? Are there simpler, safer options? What if I do nothing?”
  • Medical schools should ensure that students develop a good understanding of risk alongside critical evaluation of the literature and transparent communication. Students should be taught about overuse of tests and interventions. Organisations responsible for postgraduate and continuing medical education should ensure that practising doctors receive the same education.

In essence,  Malhotra says, the analysis marks the time to “truly wind back the harms of too much medicine”.